TY - JOUR
AU - Lindley Richard
AU - Mitchell P.
AU - De Silva D.
AU - Woon F.
AU - Manzano J.
AU - Liu E.
AU - Chang H.
AU - Wang J.
AU - Wong T.
AU - Wong M.
AU - Lee M.
AU - Gan H.
AU - Chen C.
AB - <p>
BACKGROUND AND PURPOSE: Intracranial large artery disease (ICLAD) is a major cause of ischemic stroke. Retinal microvascular changes are associated with stroke, including small vessel cerebral disease and extracranial carotid disease. We examined the relationship between ICLAD and retinal microvascular changes. METHODS: This is a prospective cohort of 802 acute ischemic stroke patients. Retinal changes were assessed from photographs by graders masked to clinical data. ICLAD was evaluated using prespecified criteria. RESULTS: ICLAD was not associated with ipsilateral retinal arteriolar/venular caliber, focal arteriolar narrowing, or arteriovenous nicking. Severe enhanced arteriolar light reflex was independently associated with any ICLAD (P=0.006) and severe ICLAD (P&lt;0.001). CONCLUSIONS: Enhanced arteriolar light reflex, but not retinal vessel caliber, was related to ICLAD. These data suggest that retinal microvascular signs have specific associations with large cerebral vessel disease.
</p>

AD - Department of Neurology, Singapore General Hospital, Outram Road, Singapore 169608. gnrdsd@sgh.com.sg
AN - 21257821
BT - Stroke
ET - 2011/01/25
LA - eng
M1 - 3
N1 - De Silva, Deidre AManzano, Jennifer J FWoon, Fung-PengLiu, Erica YangLee, Moi-PinGan, Hui-YeeChen, Christopher P L HChang, Hui-MengMitchell, PaulWang, Jie JinLindley, Richard IWong, Tien-YinWong, Meng-CheongComparative StudyMulticenter StudyResearch Support, Non-U.S. Gov'tUnited StatesStroke; a journal of cerebral circulationStroke. 2011 Mar;42(3):812-4. Epub 2011 Jan 21.
N2 - <p>
BACKGROUND AND PURPOSE: Intracranial large artery disease (ICLAD) is a major cause of ischemic stroke. Retinal microvascular changes are associated with stroke, including small vessel cerebral disease and extracranial carotid disease. We examined the relationship between ICLAD and retinal microvascular changes. METHODS: This is a prospective cohort of 802 acute ischemic stroke patients. Retinal changes were assessed from photographs by graders masked to clinical data. ICLAD was evaluated using prespecified criteria. RESULTS: ICLAD was not associated with ipsilateral retinal arteriolar/venular caliber, focal arteriolar narrowing, or arteriovenous nicking. Severe enhanced arteriolar light reflex was independently associated with any ICLAD (P=0.006) and severe ICLAD (P&lt;0.001). CONCLUSIONS: Enhanced arteriolar light reflex, but not retinal vessel caliber, was related to ICLAD. These data suggest that retinal microvascular signs have specific associations with large cerebral vessel disease.
</p>

PY - 2011
SN - 1524-4628 (Electronic)0039-2499 (Linking)
SP - 812
EP - 4
T2 - Stroke
TI - Associations of retinal microvascular signs and intracranial large artery disease
VL - 42
ER -