TY - JOUR AU - Wu J. AU - Song X. AU - Yang J. AU - Mozaffarian D. AU - Akintoye E. AU - Hou T. AU - Hammock B. AB -
Objective Our objective was to assess the dynamics of monoepoxides derived from polyunsaturated fatty acids (MEFAs), and their response to n-3 PUFA supplementation, in the setting of acute tissue injury and inflammation (cardiac surgery) in humans. Methods and Results 479 patients undergoing cardiac surgery in three countries were randomized to peri-operative fish oil (EPA+DHA; 8-10g over 2-5 days pre-operatively then 2 g/d post-operatively) or placebo (olive oil). Plasma MEFAs derived from n-3 and n-6 PUFA were measured 2 days post-operatively. Based on serial measures in a subset of the placebo group, levels of all MEFAs declined from enrollment to post-op day 2, with declines ranging from 37 to 63% (P<0.05 each). Compared to placebo at post-op day 2, levels of EPA- and DHA-derived MEFAs were 40% and 18% higher, respectively (P
AD - Wayne State University School of Medicine, United States;Objective Our objective was to assess the dynamics of monoepoxides derived from polyunsaturated fatty acids (MEFAs), and their response to n-3 PUFA supplementation, in the setting of acute tissue injury and inflammation (cardiac surgery) in humans. Methods and Results 479 patients undergoing cardiac surgery in three countries were randomized to peri-operative fish oil (EPA+DHA; 8-10g over 2-5 days pre-operatively then 2 g/d post-operatively) or placebo (olive oil). Plasma MEFAs derived from n-3 and n-6 PUFA were measured 2 days post-operatively. Based on serial measures in a subset of the placebo group, levels of all MEFAs declined from enrollment to post-op day 2, with declines ranging from 37 to 63% (P<0.05 each). Compared to placebo at post-op day 2, levels of EPA- and DHA-derived MEFAs were 40% and 18% higher, respectively (P
PY - 2016 SN - 0022-2275 (Electronic)