TY - JOUR AU - Wu J. AU - Song X. AU - Yang J. AU - Mozaffarian D. AU - Akintoye E. AU - Hou T. AU - Hammock B. AB -

Objective Our objective was to assess the dynamics of monoepoxides derived from polyunsaturated fatty acids (MEFAs), and their response to n-3 PUFA supplementation, in the setting of acute tissue injury and inflammation (cardiac surgery) in humans. Methods and Results 479 patients undergoing cardiac surgery in three countries were randomized to peri-operative fish oil (EPA+DHA; 8-10g over 2-5 days pre-operatively then 2 g/d post-operatively) or placebo (olive oil). Plasma MEFAs derived from n-3 and n-6 PUFA were measured 2 days post-operatively. Based on serial measures in a subset of the placebo group, levels of all MEFAs declined from enrollment to post-op day 2, with declines ranging from 37 to 63% (P<0.05 each). Compared to placebo at post-op day 2, levels of EPA- and DHA-derived MEFAs were 40% and 18% higher, respectively (P

AD - Wayne State University School of Medicine, United States;
The George Institute for Global Health, Australia;
Harvard Universtiy School of Public Health, United States;
Fred Hutchinson Cancer Research Center, United States;
UC Davis Comprehensive Cancer Center, University of California Davis, United States;
UC Davis, United States;
Friedman School of Nutrition Science & Policy, Tufts University dariush.mozaffarian@tufts.edu. AN - 26749073 BT - Journal of Lipid Research DA - 93562401117 DP - NLM ET - 2016/01/11 LA - Eng LB - FY16
AUS
FP M1 - 3 N1 - Akintoye, Emmanuel
Wu, Jason H Y
Hou, Tao
Song, Xiaoling
Yang, Jun
Hammock, Bruce
Mozaffarian, Dariush
J Lipid Res. 2016 Jan 9. pii: jlr.P062398. N2 -

Objective Our objective was to assess the dynamics of monoepoxides derived from polyunsaturated fatty acids (MEFAs), and their response to n-3 PUFA supplementation, in the setting of acute tissue injury and inflammation (cardiac surgery) in humans. Methods and Results 479 patients undergoing cardiac surgery in three countries were randomized to peri-operative fish oil (EPA+DHA; 8-10g over 2-5 days pre-operatively then 2 g/d post-operatively) or placebo (olive oil). Plasma MEFAs derived from n-3 and n-6 PUFA were measured 2 days post-operatively. Based on serial measures in a subset of the placebo group, levels of all MEFAs declined from enrollment to post-op day 2, with declines ranging from 37 to 63% (P<0.05 each). Compared to placebo at post-op day 2, levels of EPA- and DHA-derived MEFAs were 40% and 18% higher, respectively (P

PY - 2016 SN - 0022-2275 (Electronic)
0022-2275 (Linking) SP - 492 EP - 8 T2 - Journal of Lipid Research TI - Effect of Fish Oil on Monoepoxides Derived from Fatty Acids during Cardiac Surgery VL - 57 Y2 - FY16 ER -