Background:Patients with advanced chronic kidney disease (CKD), including end-stage kidney disease (ESKD) patients receiving dialysis, are at increased risk of cardiovascular mortality, thrombotic cardiovascular events, and major bleeding complications. No trial has investigated effectiveness of antithrombotic agents in the prevention of cardiovascular events or death specifically in people with advanced stages of CKD or ESKD.Aim:To determine whether low dose rivaroxaban (2.5 mg twice daily), compared to placebo, significantly reduces the risk of a composite outcome of;Cardiovascular death,Non-fatal myocardial infarction,Stroke, orPeripheral arterial disease events,in patients with CKD stages 4 or 5 or dialysis-dependent ESKD, and an elevated cardiovascular risk (marked by the presence of coronary artery disease or peripheral arterial disease, or non-haemorrhagic non-lacunar stroke OR diabetes mellitus OR age ≥65 years).Research Methodology:The TRACK trial is an investigator-initiated, multicentre, internat

The Botnar Child Road Safety Challenge (BCRSC), funded by Fondation Botnar and managed by the Global Road Safety Partnership, is a programme that aims to reduce road traffic deaths and injuries. The BCRSC is designed to address locally relevant road safety problems that affect children in small- and mid-sized cities in seven priority countries (India, Mexico, Romania, South Africa, Tunisia, Tanzania and Vietnam) with practical, innovative and evidence-based interventions. The George Institute for Global Health is conducting monitoring for the BCRSC in order to assess the impact of interventions undertaken in terms of lives saved and crashes averted, process indicators (behaviour, knowledge, attitude), as well as outputs. As part of this work, The George Institute developed a set of four guidance notes under a Botnar Child Road Safety Challenge Toolkit to assist grantees. They are published here as they may be useful to other project teams working in similar contexts and employing Knowledge Action and

The national tuberculosis strategic plan for 2017-22 envisages allocating substantial funds to mitigate the financial hardships of tuberculosis patients in India. Plans are underway to reimburse travel expenses for diagnostic and treatment purposes and financial assistance to cover the cost of nutritional support during treatment. However, it is well accepted that globally tuberculosis control programmes remain under funded and this is particularly true for India as its health budget is one of the lowest in the world. Therefore, to ensure proper utilization of the available resources and to plan for any social protection measures for tuberculosis patients, cost information regarding the disease is important. There is clear dearth of a comprehensive cost study on tuberculosis in India. The proposed study will be an attempt toward to fill this gap. Aim:   To estimate the cost of treating drug susceptible and multi drug resistant tuberculosis in India from a patient’s perspective. The study will do

Background According to World Health Organization (WHO), Worldwide, 10% of children and adolescents experience a mental disorder. In India, they are key contributors to the demographic dividend. Adolescence is a vulnerable period with rapid changes in physical, mental, and social levels. It is estimated that the majority of adolescent mental disorders globally are left untreated and unidentified. Several risk factors are associated with mental disorders among adolescents, especially those living in deprived living conditions like slums face situations of violence, deprivation, social vulnerability, substance abuse/ use etc. Hence, predisposing adolescents to both poor mental and physical health. There has been a rapid growth in the urban population and more than 65 million inhabitants live in almost 14 million urban slum households in India. Slums have inadequate housing, unhealthy and poor living conditions, and inadequate systems to benefit from government schemes. In addition, members residing in suc

Background Many health conditions are preventable if risk factors are identified early. Australian women have a high burden of modifiable risk factors including 60 percent being overweight or obese, and 20 percent having uncontrolled high blood pressure. Unfortunately there are many barriers that prevent women from visiting a health care professional and discussing their health. Hairdressers are one of the most common paid services used by Australian women, so hair salons present an opportunity to reach a large proportion of women. There is a clear need for novel approaches to engaging women on health issues, potentially including those that extend beyond traditional health care settings. Aim This study aims to understand the potential value of promoting women’s health outside traditional health care settings among female attendees at NSW hairdressing salons. Design The Hairdressers for Health study is a double-blind cluster-randomised controlled trial with a mixed-methods process evaluation.